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Beta-3 adrenergic receptors are particularly concentrated in adipose tissue, especially visceral (intra-abdominal) and brown adipose tissue

Because AOD 9604 has not completed the full clinical development pathway, its comprehensive side-effect profile in humans is not well characterised and should not be assumed to be benign

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5-Amino-1MQ targets the substrate binding site of NNMT the nicotinamide binding pocket competitively inhibiting nicotinamide methylation with an IC50 of 1.2 M under reference assay conditions

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